[Biomathematics & Bioinformatics](/majors/biological-biomedical-sciences/biomathematics-bioinformatics-computational-biology/) is a field worth comparing on the balance of cost and outcomes. A high-value program keeps cost low while graduates go on to earn well.
For its 2026 best-value ranking, College Factual looked at 31 schools to find the best return on investment for biomathematics & bioinformatics students.
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If you want to know which schools deliver the best value for the biomathematics & bioinformatics degrees they offer, see the list below.
University Of Illinois At Chicago earned the #1 spot for value among biomathematics & bioinformatics schools in the Great Lakes Region. Set in the city of Chicago, University Of Illinois At Chicago is a very large public institution. In-state tuition and fees average $15,949, while out-of-state students pay about $32,009. Students borrow a median of $20,115 to complete the biomathematics & bioinformatics program here. Biomathematics & Bioinformatics graduates of University Of Illinois At Chicago earn a median of $61,829 early in their careers. That is a strong return on a $20,115 median debt. University Of Illinois At Chicago admits about 77% of applicants.
Students looking for strong value in biomathematics & bioinformatics will find it at Indiana University Purdue University Indianapolis, which ranked #2. Indiana University Purdue University Indianapolis is a very large public school located in the city of Indianapolis. Expect in-state tuition and fees of around $10,762, while out-of-state students pay about $34,891. Typical student debt for biomathematics & bioinformatics graduates is $23,146. Soon after graduation, biomathematics & bioinformatics degree recipients from Indiana University Purdue University Indianapolis generally make around $56,930. That is a strong return on a $23,146 median debt. The acceptance rate is 76%.
University Of Michigan Ann Arbor is a great value for students pursuing a degree in biomathematics & bioinformatics, landing the #3 spot this year. Located in the city of Ann Arbor, University Of Michigan Ann Arbor is a very large public university. Expect in-state tuition and fees of around $18,848, compared with $63,081 for out-of-state students. Biomathematics & Bioinformatics graduates carry a median of $19,137 in student loans. Early-career biomathematics & bioinformatics graduates make about $71,336. Set against $19,137 in median debt, that is a healthy payoff. University Of Michigan Ann Arbor admits about 16% of applicants.
University Of Wisconsin Madison is a great value for students pursuing a degree in biomathematics & bioinformatics, landing the #4 spot this year. Located in the city of Madison, University Of Wisconsin Madison is a very large public university. The average in-state cost of tuition and fees is $11,603, compared with $42,103 for out-of-state students. Students borrow a median of $21,813 to complete the biomathematics & bioinformatics program here. Soon after graduation, biomathematics & bioinformatics degree recipients from University Of Wisconsin Madison generally make around $59,877. That is a strong return on a $21,813 median debt. Roughly 45% of applicants are accepted.
A rank of #5 makes Grand Valley State University one of the best values for biomathematics & bioinformatics. Grand Valley State University is a very large public school located in the town of Allendale. The average in-state cost of tuition and fees is $15,502, compared with $21,894 for out-of-state students. Biomathematics & Bioinformatics graduates carry a median of $26,378 in student loans. Early-career biomathematics & bioinformatics graduates make about $74,986. That is a strong return on a $26,378 median debt. Grand Valley State University admits about 83% of applicants.
University Of Chicago came in at #6 for value in biomathematics & bioinformatics this year. University Of Chicago is a very large private not-for-profit school located in the city of Chicago. Students from in state pay about $69,324 in tuition and fees. Students borrow a median of $15,854 to complete the biomathematics & bioinformatics program here. Biomathematics & Bioinformatics graduates of University Of Chicago earn a median of $99,193 early in their careers. That is a strong return on a $15,854 median debt. University Of Chicago admits about 4% of applicants.
Western Michigan University came in at #7 for value in biomathematics & bioinformatics this year. Set in the city of Kalamazoo, Western Michigan University is a large public institution. In-state tuition and fees average $15,987, with out-of-state students paying around $19,952. Students borrow a median of $27,981 to complete the biomathematics & bioinformatics program here. Biomathematics & Bioinformatics graduates of Western Michigan University earn a median of $48,966 early in their careers. That is a strong return on a $27,981 median debt. The acceptance rate is 85%.
Loyola University Chicago came in at #8 for value in biomathematics & bioinformatics this year. Set in the city of Chicago, Loyola University Chicago is a large private not-for-profit institution. The average in-state cost of tuition and fees is $53,710. Biomathematics & Bioinformatics graduates carry a median of $23,521 in student loans. Early-career biomathematics & bioinformatics graduates make about $58,568. Set against $23,521 in median debt, that is a healthy payoff. The acceptance rate is 82%.
Case Western Reserve University placed #9 among the best values for biomathematics & bioinformatics. Case Western Reserve University is a large private not-for-profit school located in the city of Cleveland. Students from in state pay about $66,608 in tuition and fees. Typical student debt for biomathematics & bioinformatics graduates is $25,106. Early-career biomathematics & bioinformatics graduates make about $74,459. Weighed against typical debt, the earnings make a compelling case for value. Case Western Reserve University admits about 36% of applicants.
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Notes and References
The ranking above is published by College Factual (MF_RANKING_2025), 2026 edition. The methodology weighs the cost of a degree against the earnings graduates go on to achieve, drawn primarily from the U.S. Department of Education (IPEDS and College Scorecard).
Ranking method: College Major Best Value · 31 schools evaluated.
*Averages shown above reflect the top 7 ranked schools only.
- The Integrated Postsecondary Education Data System (IPEDS) from the National Center for Education Statistics (NCES), a branch of the U.S. Department of Education (DOE), serves as the core of our data about colleges.
- Some other college data, including much of the graduate earnings data, comes from the U.S. Department of Education’s (College Scorecard).
More about our data sources and methodologies.
