[Medical Informatics](/majors/health-care-professions/medical-illustration-informatics/medical-informatics/) degree programs vary widely in price and payoff across the country. The schools below stand out for delivering a strong medical informatics education at a price that pays off.
College Factual analyzed 6 schools to build this 2026 ranking of the best value medical informatics schools.
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If you want to know which schools deliver the best value for the medical informatics degrees they offer, see the list below.
Leading the list is University Of South Carolina Upstate, our #1 best value for medical informatics in South Carolina. Located in the suburb of Spartanburg, University Of South Carolina Upstate is a moderately-sized public university. Expect in-state tuition and fees of around $11,588, with out-of-state students paying around $23,090. Students borrow a median of $30,289 to complete the medical informatics program here. Soon after graduation, medical informatics degree recipients from University Of South Carolina Upstate generally make around $39,473. That is a strong return on a $30,289 median debt. University Of South Carolina Upstate admits about 67% of applicants.
The strong cost-to-outcome balance at Limestone College earned it the #2 place for medical informatics. Set in the town of Gaffney, Limestone College is a mid-sized private not-for-profit institution. In-state tuition and fees average $27,800. Students borrow a median of $34,945 to complete the medical informatics program here. Medical Informatics graduates of Limestone College earn a median of $38,973 early in their careers. Set against $34,945 in median debt, that is a healthy payoff. Limestone College admits about 97% of applicants.
A rank of #3 makes University Of South Carolina Columbia one of the best values for medical informatics. Set in the city of Columbia, University Of South Carolina Columbia is a very large public institution. The average in-state cost of tuition and fees is $12,688, compared with $36,298 for out-of-state students. Students borrow a median of $24,472 to complete the medical informatics program here. Early-career medical informatics graduates make about $54,087. Set against $24,472 in median debt, that is a healthy payoff. Roughly 60% of applicants are accepted.
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Notes and References
This ranking is produced by College Factual (MF_RANKING_2025), 2026 edition. Schools are scored on the balance of cost (tuition and student debt) against student outcomes (post-graduation earnings) — a measure of return on investment, drawn primarily from the U.S. Department of Education (IPEDS and College Scorecard).
Ranking method: College Major Best Value · 6 schools evaluated.
*Averages shown above reflect the top 3 ranked schools only.
- The Integrated Postsecondary Education Data System (IPEDS) from the National Center for Education Statistics (NCES), a branch of the U.S. Department of Education (DOE), serves as the core of our data about colleges.
- Some other college data, including much of the graduate earnings data, comes from the U.S. Department of Education’s (College Scorecard).
More about our data sources and methodologies.
